Job Description

Metric Bio has partnered with a biotech renowned for its innovative approach in immunology, oncology, and metabolic diseases, leveraging a sophisticated discovery engine that combines computational chemistry and structure-based drug design with deep biological expertise. Focused on designing potent and selective small molecule compounds, with over a decade of success, we've built a world-class team in computationally driven drug discovery and early clinical development.

The Director of Medicinal Chemistry will report to the VP of Medicinal Chemistry and play a critical role in advancing multiple small molecule drug discovery campaigns. They will combine scientific decision-making with organizational leadership to drive projects from hit identification to development candidate.

You Will:

• Lead multidisciplinary drug discovery chemistry teams in a fast-paced, results-driven environment.
• Design, implement, and execute robust medicinal chemistry strategies to meet project objectives.
• Establish and maintain partnerships to leverage external expertise and resources.
• Collaborate effectively with various departments, functions, and leadership team members to align on project goals and strategies.
• Plan and allocate resources effectively to optimize project outcomes.
• Provide strategic, scientific, and managerial guidance within an outsourced medicinal and synthetic chemistry framework.
• Contribute to the overall scientific direction and success of the organization's current and future pipeline.

Qualifications:

• Ph.D. or equivalent in Synthetic Organic Chemistry, Medicinal Chemistry, or a related field.
• 10+ years of drug discovery experience within the biopharmaceutical industry, including a strong track record of scientific innovation and success in delivering clinical candidates.
• In-depth understanding of drug discovery processes, including ADME/PK, pharmacology, physicochemical property optimization, computational chemistry, and safety/toxicology considerations.
• Established record of success in applying structure-based drug design to clinical candidates.
• Experience leading multidisciplinary drug discovery teams from hit identification to development candidate and beyond.
• Significant experience managing synthetic chemistry activities with CROs in Asia and/or Eastern Europe.
• Strong organizational, interpersonal, communication, and managerial skills, with the ability to motivate and inspire teams to achieve scientific objectives.

Culture: We value a fast-paced, entrepreneurial, intellectually stimulating, and collaborative environment. We strive for excellence, teamwork, and authentic communication, building a community that brings out the best in each other both professionally and personally.

Founded in 2009, we are a private, growing biotechnology company headquartered in Boston, Massachusetts. For more information, visit our website.

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